Анотация: The influence of different way of cultivation on lettuce yield and quality was studied. Two field experiments were carried out on alluvial meadow soil in Tsalapitsa experimental station. The experiments were performed with lettuce, grown as a spring crop and winter crop with application of three fertilizer sources: mineral fertilizer, farmyard manure and foliar fertilization. Significantly higher yield values from lettuce were obtained when lettuce was grown both at spring and winter lettuce crop in the variants with mineral fertilization. The best quality parameters: high values of soluble sugars and vitamin C content, low level of cellulose and reduced nitrate content were observed in the variants with foliar fertilization