
Elad, D.; Blum, S.; Fleker, M.; Zukin, N.; Weissblit, L.; Shlomovitz, S.
Analysis of long term (20 years) in vitro susceptibility to antibacterial drugs of the most prevalent animal bacterial pathogens isolated in Israel. Part 2: Multi-drug resistance
Източник: ISRAEL JOURNAL OF VETERINARY MEDICINE
Година на издаване: 2012 г.
Брой: 67, 3
Страници: p. 133-138
Държател: TUN
Сигнатура: A 368
Ключови думи: multi drug resistant
Анотация: This part of the study is based on the data presented in Part 1 in the Israel Journal of Veterinary Medicine. Changes in the number of antibacterial drugs to which each microorganism was susceptible and possible correlation between all the combinations of susceptibility curves were evaluated. Results indicated a decrease in the number of drugs to which the microorganisms were resistant to, for Salmonella enterica serogroup B and Proteus spp. The number of drugs to which E. coli showed resistance decreased but returned to the original level. The low number of drugs (n=4) that were used for Pseudomonas aeruginosa made the identification of variations difficult. It was found that while stability was maintained until 2007, the number of resistant drugs decreased steeply in 2008 and somewhat increased in 2009. For Pasteurella multocida and Mannheimia haemolytica, the number of antibacterial drugs to which there was a resistance remained practically unchanged. No noteworthy patterns of correlation between susceptibility curves were observed with the exception of chloramphenicol and sulfamethoxazole/trimethoprim that had a high correlation coefficient for 3 out of the 6 included microorganisms: E. coli, Proteus spp. and P. multocida. These fndings are in general in agreement with those of Part 1 of this study and stress the importance of conducting long term surveys before reaching conclusions regarding the evolution of bacterial resistance and multi-resistance



