Description: Decoding mechanisms for hypo-and anabiosis at low temperature adaptations is of primary importance to the life activity of all organisms.. - The collection of many scientific investigations in the area of cryobiology has determined lots of factors, destroying the biological systems under cryogenic treatment.. - Up to the present there is no information available regarding the application of cellulose derivatives as cryoprotective media during freezing and lyophilization of foods and microorganisms- lactic acid bacteria, yeasts etc.. - In the paper the authors present the possibilities for application of some types of modified synthetic hydrocolloids (Na-carboxymethylcellulose and methylcellulose) as cryoprotective media for probiotics cryoconservation