Description: The liver enzyme lipoprotein lipase (LPL) facilitates the release of cholesterol from lipoproteins and plays a key role in the synthesis of steroid hormones in the adrenal glands. For the current study, 6 male and 6 female clinically healthy New Zealand White rabbits, aged 3.5 months were used. Enzyme histochemical reaction (per Gomori) was performed on fresh cryostat sections, and through the Tween method, a strong positive expression of LPL in the sinusoid capillaries of the liver lobules, the lumen, and the smooth muscle cells of the walls of interlobular arteries and veins was shown. A moderate LPL expression in zona glomerulosa and weak expression in zona fasciculata were observed in the adrenal glands, whereas no LPL expression was found in both the cortical zona reticularis and the adrenal medulla