Description: Studies on the anti-louse activity of aqueous tobacco extract in heavily parasitized West African dwarf goats are reported. The goats were allotted into three treatment groups of six animals each, viz: ivermectin treatment (subcutaneous injection of 0.5mg/kg bodyweight ivermectin); tobacco extract treatment (topical application of undiluted tobacco juice) and the untreated control. The assessment of depth of infestation and cure was based on the geometric mean of the louse counts. The geometric mean louse count decreased from 1690.71 to 2.62 (99.84 percentage efficacy) by day 14 in ivermectin treatment; while it decreased from 1627.39 to 0 (100 percentage efficacy) in the tobacco extract treatment. The geometric mean louse counts continued to increase in the untreated control group. There were increases in liveweight gains in the ivermectin and tobacco treated groups against the corresponding loss in weight recorded in the untreated control. At 78 days post-challenge employing two louse-infested goats, significant louse count could not be registered in the tobacco-treated goats. It is concluded that tobacco extract treatment proved a better therapy than ivermectin in the cure of Linognathus vituli lice species infestation of West African dwarf goats