Description: An incidence of mulberry silkworm poisoning with residual amounts of the neonicotinoid chemicals Actara and Confidor is presented in the paper. The development and final outcome of toxic poisoning is described in detail. Poisoning with Actara and Confidor occurs very quickly (within 30 min for Confidor and within 1-2 h for Actara, contrary to poisoning with nicotine (within about 2-3 days). The nervous system is affected and the mulberry silkworm body changes in size, shape and structure