Анотация: Guided bone regeneration (GBR) is most effective when the material used has osteogenic, osteoinductive and osteoconductive properties. Xenografts have limited biological properties, so a solution for diversification the properties of Bio Oss was sought by comнbiнning with Emdogain. The purpose of the present work was to study the process of GBR involving a combination of Bio Oss and Emdogain compared with their independent use. An in vivo experiment was conducted with 10 New Zeaнland white rabbits. Artificial bone defects in the tibias and femurs of each rabbit were created. Depending of the used grafting materials, six experimental groups were formed: groups 1 and 2 (Bio Oss); groups 3 and 4 (Emdogain) and groups 5 and 6 (Bio Oss + Emdogain). In control groups (A and B), osseous coagulum was used as grafting material. Prior to apposition and soft tissue suturing, all bone defects were covered with Bio Gide membrane. Half of the rabbits (groups 1, 3, 5 and control group A) were euthanised at the end of the third, and groups 2, 4, 6 and control B - of the fourth month. There were no significant quality differences between experimental and control groups by the end of month 3 or 4. Osteoblasts, osteoclasts, osteoid and woven bone were found in all the samples studied. Maturing woven and lamellar bone were found in samples treated with Bio Oss + Emdogain. Newly formed bone was in close contact with Bio Oss particles. Connective tissue around the Bio Oss particles was found only in the groups in which it was the sole material used. There was neither evidence for degradation of Bio Oss particles, nor for inflammation. The combination of osteoconductive properties of Bio Oss with osteoinductive potential of Emdogain benefited the formation of new woven bone, its transformation into lamellar and the osteointegration of Bio Oss particles