Анотация: This review is an attempt for a brief tracing of the main moments in the development of isolated perfused kidney method. It is emphasized the significance of this model and its application in various fields of science. The versatility of the isolated perfused kidney method is useful for modulating a number of pathophysiological processes, which could be helpful in studying and improving a better treatment. Isolated perfused kidney could be beneficial in the establishment of the preservation techniques used in kidney transplantation.The opportunities for the surgical procedures, the study design, the solutions for perfusion and the possible modifications of the method are described. The purpose of this paper is to regain the value of the isolated perfused kidney. This model, although expensive and sophisticated, is still valid today, and is worth the effort to be used