Анотация: The study was conducted to investigate the effects of London rocket (Sisymbrium irio) on the general health status of goats from one side and on the blood cellular and biochemical parameters from the other. Six native breed goats, 2Ц3 years old, weighing 35Ц40 kg were fed daily on 10 g/kg body weight of fresh whole plant material of London rocket (Sisymbrium irio) for five weeks. Blood samples were obtained from all animals on a weekly basis and were subjected to laboratory evaluation. Two goats were euthanised and post mortem examination was carried out. The obtained results revealed a slight effect on the general health status of the animals and no abnormal macroscopic lesions on post mortem examination. Blood biochemical analysis revealed significant elevations (P<0.05) in the mean values of alanine aminotransferase, aspartate aminotransferase, urea, magnesium, total protein and albumin starting from the third week of S. irio supplementation. Also, the results revealed non-significant changes in the mean inorganic phosphate, calcium, glucose, creatinine and uric acid concentrations compared to healthy controls. Haematological evaluation revealed significantly (P<0.05) higher total white blood cell counts and granulocytes starting from the third week of S. irio feeding. Significant (P<0.05) reductions in the mean red blood cell and lymphocyte counts were reported. It could be concluded that Sisymbrium irio altered blood biochemical and haematological parameters which may result in adverse effects on goats` health. However this assumption should be supported by further investigations