Анотация: The efficacy of herbal extracts from the plants Vitex negundo and Acorus calamus against tick infestation in rat snakes (Ptyas mucosus) maintained under captivity was studied and compared to that of Ivermectin. A total of 6 rat snakes affected with heavy tick infestation were taken for the study. Investigation of ectoparasites in snakes under captivity showed abundance of Aponomma sp. ticks