Анотация: The aim of this study was to isolate beta-haemolytic Aeromonas hydrophila strains from live rainbow trouts (Oncorhynchus mykiss) destined for human consumption and to investigate their resistance to antimicrobial drugs. Sterile swab samples were collected from 52 rainbow trouts. Fifteen (28.8%) beta-haemolytic Aeromonas strains were isolated from collected 52 swab samples. Through API 20 NE, 12 of them were identified as A. hydrophila. The sensitivity of 8 isolates to antimicrobial drugs and drug combinations was determined using MICRONAUT-SB Varia KH I 2 microplates. All isolates were sensitive to ceftazidime, ciprofloxacin, co-trimoxazole and levofloxacin, and resistant to amikacin, amoxicillin/clavulanic acid, ampicillin/sulнbactam, cefazolin, cefotiam, clindamycin, erythromycin, imipenem, linezolid, meropenem, teicoplanin and vancomycin. The percentages of resistance of isolates to the other tested chemotherapeutic drugs were variable. The presence of beta-haemolytic A. hydrophila strains, resistant to antimicrobial drugs in rainbow trouts poses a potential risk for consumers' health.