Description: Brucellosis is an endemic zoonosis in Syria, affecting both humans and animals. Data regarding suitable antibiotic combinations in post-exposure prophylaxis against Brucella melitensis infections are rare. Prophylactic effects of some antibiotic combinations were assessed in BALB/c mice, to limit or control infection by B. melitensis 16M. Antibiotics were administrated prior to (for 7 days), after or at the same time as (for 5 days) the bacterial administration