Description: The objective of this study has been the highlight of the rams` scrapie resistant genotype profile in a Romanian sheep farm from the southeast area. Twenty-five breeding rams were genotyped. Most of the rams were in second class (56%), meaning sheep genetically resistant to scrapie, but asking a special attention to be used in selection programmes. In the first class (genotype ARR/ARR) we found only one ram (4%) that makes very difficult the genetic selection. The ARQ variant was the most frequent (56%). The results of this study prove the importance of sequence-based genotype investigations in the sheep-breeding management. Those data support the scrapie control and eradication programmes based on the gradual elimination of alleles associated with scrapie susceptibility and the use of the ARR/ARR genotype rams in breeding programmes